by Ruth Y. Wetmore, 2006

During the Tuscarora War (1711-13), the Pamlico were one of the smaller tribes that joined the Tuscarora faction. After the Barnwell expedition against Tuscarora strongholds in 1712, the smaller tribes (Coree, Bay River, and Pamlico) continued to attack settlers along the Neuse and Pamlico Rivers. In the treaty that ended the war, the Tuscarora agreed to destroy their former allies, including the Pamlicos, whom the colonists still considered dangerous. Any Pamlico Indians who survived were probably enslaved or incorporated into the Tuscarora tribe.